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1

CRISPR–Cas9 Structures and Mechanisms

Jiang, Fuguo, Doudna, Jennifer A.

Journal:

Annual Review of Biophysics

Year:

2017

Language:

english

File:

PDF, 4.83 MB

english, 2017

2

CRISPR-Cas guides the future of genetic engineering

Knott, Gavin J., Doudna, Jennifer A.

Journal:

Year:

2018

Language:

english

File:

PDF, 592 KB

english, 2018

3

Biotechnology: Rewriting a genome

Charpentier, Emmanuelle, Doudna, Jennifer A.

Journal:

Year:

2013

Language:

english

File:

PDF, 353 KB

english, 2013

4

Molecular Mechanisms of RNA Interference

Wilson, Ross C., Doudna, Jennifer A.

Journal:

Annual Review of Biophysics

Year:

2013

Language:

english

File:

PDF, 1.21 MB

english, 2013

5

Cornerstones of CRISPR–Cas in drug discovery and therapy

Fellmann, Christof, Gowen, Benjamin G., Lin, Pei-Chun, Doudna, Jennifer A., Corn, Jacob E.

Journal:

Nature Reviews Drug Discovery

Year:

2016

Language:

english

File:

PDF, 3.97 MB

english, 2016

6

CRISPR germline engineering—the community speaks

Bosley, Katrine S, Botchan, Michael, Bredenoord, Annelien L, Carroll, Dana, Charo, R Alta, Charpentier, Emmanuelle, Cohen, Ron, Corn, Jacob, Doudna, Jennifer, Feng, Guoping, Greely, Henry T, Isasi, Ro

Journal:

Nature Biotechnology

Year:

2015

Language:

english

File:

PDF, 3.28 MB

english, 2015

7

Applications of CRISPR technologies in research and beyond

Barrangou, Rodolphe, Doudna, Jennifer A

Journal:

Nature Biotechnology

Year:

2016

Language:

english

File:

PDF, 1.72 MB

english, 2016

8

Voices of biotech

Amit, Ido, Baker, David, Barker, Roger, Berger, Bonnie, Bertozzi, Carolyn, Bhatia, Sangeeta, Biffi, Alessandra, Demichelis, Francesca, Doudna, Jennifer, Dowdy, Steven F, Endy, Drew, Helmstaedter, Mori

Journal:

Nature Biotechnology

Year:

2016

Language:

english

File:

PDF, 3.22 MB

english, 2016

9

Programmable RNA Tracking in Live Cells with CRISPR/Cas9

Nelles, David A., Fang, Mark Y., O’Connell, Mitchell R., Xu, Jia L., Markmiller, Sebastian J., Doudna, Jennifer A., Yeo, Gene W.

Journal:

Year:

2016

Language:

english

File:

PDF, 3.07 MB

english, 2016

10

A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9

Dagdas, Yavuz S., Chen, Janice S., Sternberg, Samuel H., Doudna, Jennifer A., Yildiz, Ahmet

Journal:

Science Advances

Year:

2017

Language:

english

File:

PDF, 2.34 MB

english, 2017

11

CRISPR System: From Adaptive Immunity to Genome Editing

Doudna, Jennifer

Journal:

Molecular Frontiers Journal

Year:

2017

Language:

english

File:

PDF, 2.31 MB

english, 2017

12

The chemical repertoire of natural ribozymes

Doudna, Jennifer A., Cech, Thomas R.

Journal:

Year:

2002

Language:

english

File:

PDF, 242 KB

english, 2002

13

Conformational control of DNA target cleavage by CRISPR–Cas9

Sternberg, Samuel H., LaFrance, Benjamin, Kaplan, Matias, Doudna, Jennifer A.

Journal:

Year:

2015

Language:

english

File:

PDF, 6.93 MB

english, 2015

14

An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3

Sashital, Dipali G, Jinek, Martin, Doudna, Jennifer A

Journal:

Nature Structural and Molecular Biology

Year:

2011

Language:

english

File:

PDF, 1.91 MB

english, 2011

15

Structural insights into RNA interference

Dipali G. Sashital, Jennifer A Doudna

Journal:

Current Opinion in Structural Biology

Year:

2010

Language:

english

File:

PDF, 892 KB

english, 2010

16

Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes

Watters, Kyle E., Shivram, Haridha, Fellmann, Christof, Lew, Rachel J., McMahon, Blake, Doudna, Jennifer A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2020

Language:

english

File:

PDF, 1.16 MB

english, 2020

17

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

Qi, Lei S., Larson, Matthew H., Gilbert, Luke A., Doudna, Jennifer A., Weissman, Jonathan S., Arkin, Adam P., Lim, Wendell A.

Journal:

Year:

2013

Language:

english

File:

PDF, 843 KB

english, 2013

18

Ribozyme Structures and Mechanisms

Doherty, Elizabeth A., Doudna, Jennifer A.

Journal:

Annual Review of Biochemistry

Year:

2000

Language:

english

File:

PDF, 2.04 MB

english, 2000

19

CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification

Oakes, Benjamin L., Fellmann, Christof, Rishi, Harneet, Taylor, Kian L., Ren, Shawn M., Nadler, Dana C., Yokoo, Rayka, Arkin, Adam P., Doudna, Jennifer A., Savage, David F.

Journal:

Year:

2019

Language:

english

File:

PDF, 8.17 MB

english, 2019

20

Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics

Ricci, Clarisse G., Chen, Janice S., Miao, Yinglong, Jinek, Martin, Doudna, Jennifer A., McCammon, J. Andrew, Palermo, Giulia

Journal:

ACS Central Science

Year:

2019

Language:

english

File:

PDF, 6.41 MB

english, 2019

21

A three-dimensional view of the molecular machinery of RNA interference

Jinek, Martin, Doudna, Jennifer A.

Journal:

Year:

2009

Language:

english

File:

PDF, 2.44 MB

english, 2009

22

RNA-guided genetic silencing systems in bacteria and archaea

Wiedenheft, Blake, Sternberg, Samuel H., Doudna, Jennifer A.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.11 MB

english, 2012

23

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

Gilbert, Luke A., Larson, Matthew H., Morsut, Leonardo, Liu, Zairan, Brar, Gloria A., Torres, Sandra E., Stern-Ginossar, Noam, Brandman, Onn, Whitehead, Evan H., Doudna, Jennifer A., Lim, Wendell A.,

Journal:

Year:

2013

Language:

english

File:

PDF, 689 KB

english, 2013

24

DNA Interrogation by the CRISPR RNA-Guided Endonuclease Cas9

Sternberg, Samuel H., Redding, Sy, Jinek, Martin, Greene, Eric C., Doudna, Jennifer A.

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 40 KB

english, 2014

25

Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity

Nuñez, James K., Lee, Amy S. Y., Engelman, Alan, Doudna, Jennifer A.

Journal:

Year:

2015

Language:

english

File:

PDF, 5.77 MB

english, 2015

26

Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch

Oakes, Benjamin L, Nadler, Dana C, Flamholz, Avi, Fellmann, Christof, Staahl, Brett T, Doudna, Jennifer A, Savage, David F

Journal:

Nature Biotechnology

Year:

2016

Language:

english

File:

PDF, 1.42 MB

english, 2016

27

Enhanced proofreading governs CRISPR–Cas9 targeting accuracy

Chen, Janice S., Dagdas, Yavuz S., Kleinstiver, Benjamin P., Welch, Moira M., Sousa, Alexander A., Harrington, Lucas B., Sternberg, Samuel H., Joung, J. Keith, Yildiz, Ahmet, Doudna, Jennifer A.

Journal:

Year:

2017

Language:

english

File:

PDF, 11.45 MB

english, 2017

28

RNA-catalysed synthesis of complementary-strand RNA

Doudna, Jennifer A., Szostak, Jack W.

Journal:

Year:

1989

File:

PDF, 444 KB

1989

29

Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System

Dipali G. Sashital, Blake Wiedenheft, Jennifer A. Doudna

Journal:

Year:

2012

Language:

english

File:

PDF, 3.50 MB

english, 2012

30

RNA-programmed genome editing in human cells

Jinek, Martin, East, Alexandra, Cheng, Aaron, Lin, Steven, Ma, Enbo, Doudna, Jennifer

Journal:

Year:

2013

Language:

english

File:

PDF, 298 KB

english, 2013

31

S TRUCTURAL I NSIGHTS I NTO THE S IGNAL R ECOGNITION P ARTICLE

Doudna, Jennifer A., Batey, Robert T.

Journal:

Annual Review of Biochemistry

Year:

2004

Language:

english

File:

PDF, 709 KB

english, 2004

32

Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System

Redding, Sy, Sternberg, Samuel H., Marshall, Myles, Gibb, Bryan, Bhat, Prashant, Guegler, Chantal K., Wiedenheft, Blake, Doudna, Jennifer A., Greene, Eric C.

Journal:

Year:

2015

Language:

english

File:

PDF, 3.35 MB

english, 2015

33

Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering

Wright, Addison V., Nuñez, James K., Doudna, Jennifer A.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.54 MB

english, 2016

34

RNA-dependent RNA targeting by CRISPR-Cas9

Strutt, Steven C, Torrez, Rachel M, Kaya, Emine, Negrete, Oscar A, Doudna, Jennifer A

Journal:

Year:

2018

Language:

english

File:

PDF, 2.13 MB

english, 2018

35

The promise and challenge of therapeutic genome editing

Doudna, Jennifer A.

Journal:

Year:

2020

File:

PDF, 1.78 MB

2020

36

The NAI Fellow Profile: An Interview with Dr. Jennifer Doudna

Doudna, Jennifer A., Macuare, Kimberly A.

Journal:

Technology & Innovation

Year:

2019

File:

PDF, 420 KB

2019

37

Tertiary Motifs in RNA Structure and Folding

Robert T. Batey, Robert P. Rambo, Jennifer A. Doudna

Journal:

Angewandte Chemie International Edition

Year:

1999

Language:

english

File:

PDF, 464 KB

english, 1999

38

Metal ions in ribozyme folding and catalysis

Raven Hanna, Jennifer A Doudna

Journal:

Current Opinion in Chemical Biology

Year:

2000

Language:

english

File:

PDF, 225 KB

english, 2000

39

RNA processing enables predictable programming of gene expression

Qi, Lei, Haurwitz, Rachel E, Shao, Wenjun, Doudna, Jennifer A, Arkin, Adam P

Journal:

Nature Biotechnology

Year:

2012

Language:

english

File:

PDF, 743 KB

english, 2012

40

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

Pattanayak, Vikram, Lin, Steven, Guilinger, John P, Ma, Enbo, Doudna, Jennifer A, Liu, David R

Journal:

Nature Biotechnology

Year:

2013

Language:

english

File:

PDF, 529 KB

english, 2013

41

Insights into RNA structure and function from genome-wide studies

Mortimer, Stefanie A., Kidwell, Mary Anne, Doudna, Jennifer A.

Journal:

Nature Reviews Genetics

Year:

2014

Language:

english

File:

PDF, 1.31 MB

english, 2014

42

Programmable RNA recognition and cleavage by CRISPR/Cas9

O’Connell, Mitchell R., Oakes, Benjamin L., Sternberg, Samuel H., East-Seletsky, Alexandra, Kaplan, Matias, Doudna, Jennifer A.

Journal:

Year:

2014

Language:

english

File:

PDF, 4.93 MB

english, 2014

43

Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity

Kranzusch, Philip J., Lee, Amy S.Y., Wilson, Stephen C., Solovykh, Mikhail S., Vance, Russell E., Berger, James M., Doudna, Jennifer A.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.36 MB

english, 2014

44

Rational design of a split-Cas9 enzyme complex

Wright, Addison V., Sternberg, Samuel H., Taylor, David W., Staahl, Brett T., Bardales, Jorge A., Kornfeld, Jack E., Doudna, Jennifer A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.09 MB

english, 2015

45

The structural biology of CRISPR-Cas systems

Jiang, Fuguo, Doudna, Jennifer A

Journal:

Current Opinion in Structural Biology

Year:

2015

Language:

english

File:

PDF, 2.67 MB

english, 2015

46

Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering

Nuñez, James K., Harrington, Lucas B., Doudna, Jennifer A.

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 3.52 MB

english, 2016

47

Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes

Staahl, Brett T, Benekareddy, Madhurima, Coulon-Bainier, Claire, Banfal, Ashwin A, Floor, Stephen N, Sabo, Jennifer K, Urnes, Cole, Munares, Gabriela Acevedo, Ghosh, Anirvan, Doudna, Jennifer A

Journal:

Nature Biotechnology

Year:

2017

Language:

english

File:

PDF, 1.89 MB

english, 2017

48

High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding

Boyle, Evan A., Andreasson, Johan O. L., Chircus, Lauren M., Sternberg, Samuel H., Wu, Michelle J., Guegler, Chantal K., Doudna, Jennifer A., Greenleaf, William J.

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 1.46 MB

english, 2017

49

Enhanced Proofreading Governs CRISPR-Cas9 Targeting Accuracy

Chen, Janice S., Dagdas, Yavuz S., Kleinstiver, Benjamin P., Welch, Moira M., Sousa, Alexander A., Harrington, Lucas B., Sternberg, Samuel H., Joung, Keith J., Yildiz, Ahmet, Doudna, Jennifer A.

Journal:

Biophysical Journal

Year:

2018

Language:

english

File:

PDF, 44 KB

english, 2018

50

CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions

Hultquist, Judd F., Hiatt, Joseph, Schumann, Kathrin, McGregor, Michael J., Roth, Theodore L., Haas, Paige, Doudna, Jennifer A., Marson, Alexander, Krogan, Nevan J.

Journal:

Nature Protocols

Year:

2018

Language:

english

File:

PDF, 986 KB

english, 2018

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